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Virology Ph. D Program at Harvard. Gack, M. U., Shin, Y. C., Joo, C. H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z., Inoue, S., & Jung, J. U. TRIM2. 5 RING- finger E3 ubiquitin ligase is essential for RIG- I- mediated antiviral activity.
BS/MS Program in Immunology, Microbiology and Virology. The application deadline for Fall is May 1st each year. Interested students are strongly encouraged to contact. This Columbia University virology course is offered each year in the spring semester by Vincent Racaniello.
- Biology Honors Program Participating in the honors program allows students to develop their research skills, deepen their understanding of the field, and.
- Institute for Molecular Virology Training Program The IMV Training Program (IMVTP) is supported by NIH grant T32 AI83196. The overarching research theme of the IMV.
- The Institute for Molecular Virology.
Gack, M. U., Kirchhofer, A., Shin, Y. C., Inn, K., Liang, C., Cui, S., Myong, S., Ha, T. K., Hopfner, K. P., & Jung, J. U. Roles of RIG- I N- terminal tandem CARD and splice variant in TRIM2. Myong, S., Cui, S., Cornish, P. V., Kirchhofer, A., Gack, M. U., Jung, J. U., Hopfner, P.
Virology Departments and Institutes. This is a collection of the web sites of virology departments of universities and research institutes around the world.
Cytosolic viral sensor RIG- I is a 5’- triphosphate- dependent translocase on double- stranded RNA. Feb 2. 0; 3. 23(5. Gack, M. U., Albrecht, R.
A., Urano, T., Inn, K., Huang, I. C., Carnero, E., Farzan, M., Inoue, S., Jung, J. U. Influenza A virus NS1 targets the ubiquitin ligase TRIM2.
RIG- I. May 8; 5(5): 4. Gack, M. U., Nistal- Vill. Phosphorylation- mediated negative regulation of RIG- I anti- viral activity. J Virol 8. 4(7): 3. Nistal- Vill. Negative Role of RIG- I Serine 8 Phosphorylation in the regulation of IFN- . Inn, K. S., Gack, M. U., Tokunaga, F., Shi, M., Wong, L.
Y., Iwai, K., and Jung J. U. Linear ubiquitin assembly complex negatively regulates RIG- I- and TRIM2. I interferon induction. Molecular Cell 4. Maharaj, N. P., Wies, E., Stoll, A., and Gack, M. U. Conventional protein kinase C- .
J Virol, 8. 6(3): 1. Rajsbaum, R., Albrecht, R. A., Maharaj, N. P., Wang, M. K., Versteeg, G. A., Nistal- Vill. Species- specific inhibition of RIG- I ubiquitination and IFN induction by the influenza A virus NS1 protein. Dephosphorylation of the RNA sensors RIG- I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.
Mar 2. 1; 3. 8(3): 4. Pauli, E.- K., Chan Y. K., Davis, M. E., Gableske, S., Wang, M. K., Feister, F. F., and Gack, M. U. The Ubiquitin- Specific Protease USP1. Promotes RIG- I- Mediated Antiviral Signaling by Deubiquitylating TRIM2.
Science Signaling 7, ra. Davis, M. E., Wang, M. K., Rennick, L. J., Full, F., Mesman, A. I., Geijtenbeek, T. B. H., Duprex, W. P., and Gack, M. U. Antagonism of the Phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5.